Prenatal Programming of Pulmonary Hypertension Induced by Chronic Hypoxia or Ductal Ligation in Sheep
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چکیده
منابع مشابه
Effect of thoracic epidural blockade on hypoxia-induced pulmonary arterial hypertension in rats
Objective(s): The present study was aimed to investigate the influence of thoracic epidural blockade on hypoxia-induced pulmonary hypertension in rats. Materials and Methods: Forty eight Wistar rats were randomly divided into 4 equal groups, named normoxia hypoxia hypoxia/ ropivacaine and hypoxia/saline. Animals were placed in a hypoxia chamber and instrumented with epidural catheters at the t...
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Objective(s): Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reportedto be associated with many inflammatory mediators of PAH. This study aimed to evaluate the effect of chronic intermittent hypobaric hypoxia (CIHH) on pulmonary inflammat...
متن کاملPoint:Counterpoint: Chronic hypoxia-induced pulmonary hypertension does/does not lead to loss of pulmonary vasculature POINT: CHRONIC HYPOXIA-INDUCED PULMONARY HYPERTENSION DOES LEAD TO LOSS OF PULMONARY VASCULATURE
This debate focuses on whether, and to what extent, loss of small precapillary arteries is associated with the elevation in pulmonary artery pressure and resistance that accompanies chronic hypoxia-induced pulmonary hypertension. The issue has become the focus of much debate for a number of reasons. Papers from McLoughlin and his group (5, 6) have provided conclusive evidence that there is cons...
متن کاملPulmonary hypertension due to chronic hypoxia.
Pulmonary vasoconstriction in response to hypoxia is a basic reflex that occurs in all mammals studied. It has long been thought to have two main physiological functions. In the fetus it is responsible for closing off the pulmonary circulation to prevent blood from shunting through the unventilated lung. After birth it ensures that perfusion is constantly matched to ventilation. The problem com...
متن کاملTime-dependent phenotypic and contractile changes of pulmonary artery in chronic hypoxia-induced pulmonary hypertension.
Phenotypic and contractile changes in pulmonary arterial smooth muscle cells (PASMCs) were examined in rats with pulmonary hypertension induced by hypoxia. Exposure to hypoxia induced pulmonary hypertension within 1-4 weeks. Staining with BrdU revealed that proliferative activities of PASMCs peaked at 1 week of hypoxic exposure, and then moderate proliferative activity was maintained for the ne...
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ژورنال
عنوان ژورنال: Pulmonary Circulation
سال: 2013
ISSN: 2045-8940,2045-8940
DOI: 10.1086/674767